Endocrine side effects including two cases of galactorrhea have been reported in association with sertraline (the active ingredient contained in Zoloft) therapy. Two cases of breast discomfort and enlargement without galactorrhea have also been reported. Zoloft (Sertraline) Withdrawal Timeline And Symptom Durations Around 1/5 of people who take sertraline more than six weeks may experience withdrawal symptoms from abruptly stopping the medication. Gradually tapering off Zoloft under a doctor’s supervision can reduce or avoid the symptoms altogether. Zoloft (sertraline) is an antidepressant used to treat depression and anxiety. While generally safe, there are some side effects you should watch out for. While generally safe, there are some side effects you should watch out for. However, it can cause several side effects like many other antidepressants, and its discontinuation can produce some withdrawal symptoms. Discontinuing Zoloft The withdrawal symptoms associated with this drug can occur when it is discontinued abruptly or its dosage is reduced all of a sudden. Zoloft withdrawal is highly individual and depends on many factors. So, it is hard to give a precise time frame, because druation varies considerably from one person to another. So, it is hard to give a precise time frame, because druation varies considerably from one person to another. Zoloft (Sertraline) Side Effects, Withdrawal and FAQs Home » Medications & Drugs » Antidepressants » Zoloft Zoloft (sertraline) is an antidepressant drug developed in the 1970’s, for which Pfizer received FDA approval in 1991. The symptoms of Zoloft® withdrawal are in many cases worse than the side effects. Zoloft® belongs to a category of drugs called Selective Serotonin Reuptake Inhibitors (SSRIs) that are used primarily to treat depression, and which can cause severe withdrawal once the patient stops taking them. I tried Celexa, similar to Zoloft only Zoloft has more side effects and Celexa is the newest of the SSRI's. I had bad withdrawal for about one week after I stopped taking it for having severe diahrea for over one month: a side effect. Zoloft use during pregnancy may lead to adverse effects in the newborn. It is unknown if Zoloft passes into breast milk. Consult your doctor before breastfeeding. In some patients, if Zoloft is discontinued abruptly, withdrawal side effects include abdominal cramps, flu-like symptoms, fatigue, and memory impairment. That only gave me side effects to go with the withdrawal symptoms! These doctors truly don’t have a clue on the horror of coming off antidepressants. These doctors truly don’t have a clue on the horror of coming off antidepressants.